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In general, cannot create new component components (e.g., a custom muscle; though there are some exceptions).
Cannot create plugins for use through the GUI or command-line.
In Matlab/Python, there’s no access to OpenSim's plotter (use Matlab/Python native plotter) or visualizer (use the Simbody visualizer).
Many SimTK/Simbody classes (that belong to the SimTK namespace and simbody internals) are not available (e.g., integrators).

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