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In this seminar, we will show how you can use musculoskeletal models in isolation as well as in combination with real gait analysis data to address clinically relevant research questions. Amongst others, we will show a fast and easy workflow to estimate muscle-tendon kinematics (e.g., length and moment arms), perform virtual surgeries to simple musculoskeletal systems and evaluate the impact on musculoskeletal function. Moreover, we will show how to estimate muscle force via forward and inverse dynamics formulations, e.g., use electromyography-informed simulations to account for muscle co-contractions. Participants of the seminar should bring their own laptop with pre-installed software (i.e., OpenSim 4.4, Notepad++, Mokka) for carrying out the hands-on exercises. By the end of this seminar, you will understand basic principles of musculoskeletal modelling and you will be able to carry out basic analyses of musculoskeletal function.
Agenda
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1. Seminar overview
2. Introduction to the OpenSim framework (+hands-on)
3. Difference conventional clinical gait model versus musculoskeletal models
4. Estimating muscle-tendon length (hands-on)
5. Data import, scaling and inverse kinematics (+hands-on)
Break 30 minutes
6. Clinical applications of musculoskeletal modelling
7. Simulating a surgery (hands-on)
8. Typical simulation pipeline (from external to internal biomechanics)
9. Impact of geometry on simulation output (hands-on)
10. EMG-informed modelling
11. Final discussion