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The workshop will first give an introduction on novel methodologies that use experimental measurements of electromyography (EMG) data as input drive for physiologically accurate and comprehensive models of the human musculoskeletal system(https://simtk.org/home/ceinms). A live software demonstration will then demonstrate real-time EMG-driven modelling on healthy individuals. The workshop will then introduce the software package OpenSim (https://simtk.org/home/opensim). In this, participants will be introduced to the theory behind simulation of musculoskeletal movement in OpenSim, along with the framework of the software architecture and functions. This will be followed by hands-on examples on how to use the GUI and API to enable participants to start using OpenSim for simulating the interaction between the human musculoskeletal system and wearable devices.